Author

Sulyman Barkho

Broad Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1 Assay:structural biology· 1

Frequent Co-Authors

Deborah Tan HungiD· 2 shared James E. GomeziD· 2 shared Andrej ŠaliiD· 1 shared Ashley Y. Eng· 1 shared Austin N. BondiD· 1 shared Cong LiuiD· 1 shared Diana K. HuntiD· 1 shared Emily J. GeddesiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersMicrobiology

Deborah Tan HungORCID

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2 papers

Recent·Most cited

Large-Scale Chemical-Genetic Interaction Profiling Identifies a Novel Small-Molecule Inhibitor of Mycobacterium tuberculosis Polyketide Synthase 13

James E. Gomez, Matthew Y. Solomon, Diana K. Hunt, Emily J. Geddes, Austin N. Bond, Cong Liu, Rebecca J Ulrich, Pooja V. Chaudhary, Sulyman Barkho, Deborah Tan Hung

This paper identifies a novel small-molecule inhibitor of Mycobacterium tuberculosis Pks13 through chemical-genetic interaction profiling and validates its mechanism of action.

ACS Infectious Diseases · May 13, 2026Peer-reviewedMicrobiology

Structure and inhibition mechanisms of Mycobacterium tuberculosis essential transporterefflux protein A

Nitesh Kumar Khandelwal, Meghna Gupta, James E. Gomez, Sulyman Barkho, Ziqiang Guan, Ashley Y. Eng, Tomohiko Kawate, Sree Ganesh Balasubramani, Andrej Šali, Deborah Tan Hung, Robert Michael Stroud

This study identifies two inhibitors of the Mtb efflux pump EfpA, determines their binding mechanisms, and suggests their potential for combination anti-tuberculosis therapy.

Nature Communications · Apr 1, 2025Peer-reviewedBiochemistry