Author

Michael G. FitzGerald

Broad InstituteORCID 0000-0002-0488-0530Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Organism:bacteria (other)· 1 Approach:deep learning· 1 Approach:experimental assay· 1

Frequent Co-Authors

Aaron J. GolasiD· 2 shared Deborah Tan HungiD· 2 shared Noam Shoresh FiD· 2 shared Allison Lemmer· 1 shared Andras BoeszoermenyiiD· 1 shared Austin N. BondiD· 1 shared Bradley E. PoulseniD· 1 shared Christopher M. SassettiiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersMicrobiology

Aaron J. GolasORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Reference-based chemical-genetic interaction profiling to elucidate small molecule mechanism of action in Mycobacterium tuberculosis

Austin N. Bond, Marek Orzechowski, Shuting Zhang, Ishay Ben-Zion, Allison Lemmer, Nathaniel Garry, Katie Lee, Michael J. Chen, Kayla Delano, Emily Gath, Aaron J. Golas, Raymond M. Nietupski, Michael G. FitzGerald, Sabine Ehrt, Eric J. Rubin, , Deborah Tan Hung

This paper introduces PCL analysis to predict small molecule mechanisms of action in Mycobacterium tuberculosis using PROSPECT data, achieving high sensitivity and precision in MOA prediction.

bioRxiv · Feb 15, 2025 · PreprintMicrobiology

Multiplexed screen identifies a Pseudomonas aeruginosa-specific small molecule targeting the outer membrane protein OprH and its interaction with LPS

Bradley E. Poulsen, Thulasi Warrier, Sulyman Barkho, Josephine Bagnall, Keith P. Romano, T. L. White, Xiao Yu, Tomohiko Kawate, Phuong H. Nguyen, Kyra Raines, Kristina M. Ferrara, Aaron J. Golas, Michael G. FitzGerald, Andras Boeszoermenyi, Virendar K. Kaushik, , Deborah Tan Hung

The paper identifies a Pseudomonas aeruginosa-specific small molecule, BRD1401, that targets OprH and disrupts its interaction with LPS, increasing membrane fluidity.

Cell chemical biology · Dec 27, 2024Peer-reviewedMicrobiology