Katelyn M. Vendrely

The paper evaluates the impact of drug resistance mutations on antimalarial drug resistance and fitness in Plasmodium falciparum isolates from Senegal using genetic and phenotypic assays.

This paper develops and validates a qPCR-based assay to measure growth, resistance, and recovery of Plasmodium falciparum after artemisinin treatment, showing distinct phenotypes with independent genetic determinants.

This study uses a genetic cross of Plasmodium falciparum isolates to analyze the roles of pfcrt and pm2/3 in piperaquine resistance and fitness traits.

This study identifies pfaat1 as a key gene in chloroquine resistance evolution in malaria parasites, showing it modulates resistance and fitness through amino acid transport.

This study optimizes bulk segregant analysis for identifying drug resistance loci in Plasmodium falciparum using genetic crosses in humanized mice, confirming the kelch13 locus and demonstrating the utility of cryopreserved pools.

This paper introduces cyclical regression covariates to remove confounding from developmental gene expression in Plasmodium falciparum, improving drug response analysis in clinical samples.