Author

Mackenzie A. C. Sievert

University of Notre Dame

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 2 Microbiology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:plant (other)· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:database / resource· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Michael T. FerdigiD· 4 shared Katelyn M. VendrelyiD· 3 shared Katrina A. Button-SimonsiD· 3 shared Ashley M. VaughaniD· 2 shared Douglas A. ShoueiD· 2 shared Gabriel FosteriD· 2 shared Jeanne Romero‐SeversoniD· 2 shared Lisa A. CheckleyiD· 2 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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4 shared papersGenomics

Michael T. FerdigORCID

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4 papers

Recent·Most cited

Measuring Growth, Resistance and Recovery after Artemisinin Treatment of Plasmodium falciparum in a semi-high-throughput Assay

Mackenzie A. C. Sievert, Puspendra P. Singh, Douglas A. Shoue, Lisa A. Checkley, Katelyn M. Vendrely, Tarrick Qahash, Zione Cassady, Sudhir Kumar, Xue Li, François Henry Nosten, Timothy J. C. Anderson, Ashley M. Vaughan, Jeanne Romero‐Severson, Michael T. Ferdig

This paper develops and validates a qPCR-based assay to measure growth, resistance, and recovery of Plasmodium falciparum after artemisinin treatment, showing distinct phenotypes with independent genetic determinants.

Malaria Journal · Aug 14, 2025Peer-reviewedMicrobiology

Enhancing gene co-expression network inference for the malaria parasite Plasmodium falciparum

Qi Li, Katrina A. Button-Simons, Mackenzie A. C. Sievert, Elias Chahoud, Gabriel Foster, Kaitlynn Meis, Michael T. Ferdig, Tijana Milenković

This paper evaluates multiple gene co-expression network inference methods for Plasmodium falciparum to improve functional annotation of its genes.

Genes · May 25, 2024Peer-reviewedSystems Biology

Using a P. falciparum genetic cross to dissect the relative contributions of pfcrt and plasmepsin II/III to piperaquine response-related traits

John Kane, Xue Li, Sudhir Kumar, Katrina A. Button-Simons, Katelyn M. Vendrely, Haley Dahlhoff, Mackenzie A. C. Sievert, Lisa A. Checkley, Douglas A. Shoue, Puspendra P. Singh, Biley A. Abatiyow, Meseret T. Haile, Shalini Nair, Ann N. Reyes, Rupam Tripura, , Michael T. Ferdig

This study uses a genetic cross of Plasmodium falciparum isolates to analyze the roles of pfcrt and pm2/3 in piperaquine resistance and fitness traits.

bioRxiv · Jun 6, 2023 · PreprintGenomics

Cyclical Regression Covariates remove the major confounding effect of cyclical developmental gene expression with strain-specific drug response in the malaria parasite Plasmodium falciparum

Gabriel Foster, Mackenzie A. C. Sievert, Katrina A. Button-Simons, Katelyn M. Vendrely, Jeanne Romero‐Severson, Michael T. Ferdig

This paper introduces cyclical regression covariates to remove confounding from developmental gene expression in Plasmodium falciparum, improving drug response analysis in clinical samples.

BMC Genomics · Mar 5, 2022Peer-reviewedGenomics