Alfred Amambua‐Ngwa

This study identifies lactylated histones as markers of virulence genes in Plasmodium falciparum, showing their enrichment at genes involved in host-cell remodelling and dynamic regulation across the cell cycle.

This study analyzes SCD demographics and clinical outcomes in Gambian cohorts, finding low crisis and infection rates without hydroxyurea use and benefits of folic acid and penicillin.

The paper compares transcript levels of invasion ligand genes in Malaysian and Gambian Plasmodium falciparum isolates, finding regional differences in eba175, eba181, and Rh2b expression.

The paper identifies genomic signatures of selection in Anopheles funestus across African populations, revealing shared and population-specific adaptive variation linked to insecticide resistance and neuromodulatory pathways.

The paper models IL-6 response in severe malaria using an ex vivo co-culture system and clinical data, showing that IL-6 is context-dependent and influenced by metabolic and thermal cues.

The paper analyzes amplicon sequencing data from 17,384 Plasmodium falciparum samples in West Africa to characterize antimalarial resistance patterns and their geographic distribution.

The paper investigates how geographical variation influences the adaptive evolution of Plasmodium falciparum mutations that counteract sickle cell trait protection.

The paper analyzes the evolution and prevalence of dhfr and dhps resistance alleles and haplotypes across Africa using whole genome data from multiple countries.

The paper analyzes old Plasmodium falciparum genomes to study malaria parasite adaptation over 50 years, finding strong positive selection at surface protein loci and changes in allele frequencies.

This study compares Plasmodium falciparum multiplication rates between hospital and community infections, finding higher rates in hospital isolates and a positive correlation with parasitaemia.

The paper identifies regional subpopulations and gene flow patterns of Plasmodium falciparum in Africa using genome-wide microsatellite loci from 992 isolates.

The paper identifies a cryptotype in Plasmodium falciparum genomes across Africa, characterized by a complex genetic background that is geographically widespread but genetically distinct.

This study identifies pfaat1 as a key gene in chloroquine resistance evolution in malaria parasites, showing it modulates resistance and fitness through amino acid transport.

The paper uses whole genome sequencing to trace the origin of SARS-CoV-2 strains in The Gambia, identifying European and Asian sources.

This study examines biting and resting preferences of malaria vectors in The Gambia, finding that An. arabiensis prefers outdoor resting while An. coluzzii prefers indoor resting, with associated insecticide resistance mutations.