Author

Aaron D. Simmons

University of Wisconsin–MadisonORCID 0000-0001-6608-0320Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2 Bioengineering· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Organism:human· 4 Assay:bulk RNA-seq· 3 Assay:metabolomics· 3 Assay:proteomics· 3 Research Focus:differential expression· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

Sean P. PalecekiD· 4 shared Austin K. FeeneyiD· 3 shared Elizabeth F. BayneiD· 3 shared Yanlong ZhuiD· 3 shared Ying GeiD· 3 shared Timothy J. KampiD· 2 shared Benjamin WancewicziD· 1 shared Chanhyung Park· 1 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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4 shared papersCell Biology

Sean P. PalecekORCID

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4 papers

Recent·Most cited

Cell BiologyJournal of Molecular and Cellular CardiologyPeer-reviewedOct 2, 2026

Multi-omic analysis reveals maturation programs in human pluripotent stem cell-derived cardiomyocytes during long-term culture

Austin K. Feeney, Aaron D. Simmons, Elizabeth F. Bayne…·Sean P. Palecek

This study identifies molecular pathways and regulatory programs associated with hPSC-CM maturation through multi-omic profiling during long-term culture.

DOI 10.1016/j.yjmcc.2026.10.001

humanmetabolomics

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Cell BiologybioRxivPreprintJan 9, 2026

Early multi-omic signatures and machine learning models predict cardiomyocyte differentiation efficiency and enable robust hPSC differentiation to cardiomyocytes

Austin K. Feeney, Aaron D. Simmons, Elizabeth F. Bayne…·Sean P. Palecek

1 citation

humanbulk RNA-seq

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BioengineeringbioRxivPreprintApr 24, 2025

Human Plasma-Like Medium Promotes Maturation of Human Pluripotent Stem Cell-Derived Cardiomyocytes

Xiaotian Zhange, Aaron D. Simmons, Kimberly S. Huggler…·Sean P. Palecek

This paper shows that Human Plasma-Like Medium (HPLM) improves the maturation of human pluripotent stem cell-derived cardiomyocytes compared to conventional media.

1 citation

humanbulk RNA-seq

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Systems BiologyJournal of Proteome ResearchPeer-reviewedSep 9, 2021

A Multi-omics Method Enabled by Sequential Metabolomics and Proteomics for Human Pluripotent Stem Cell-derived Cardiomyocytes

Elizabeth F. Bayne, Aaron D. Simmons, David S. Roberts…·Ying Ge

The paper develops a multi-omics method to analyze metabolome and proteome of hPSC-CMs, identifying overrepresented pathways in protein synthesis and cardiac function.

25 citations

humanproteomics

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