John L. Hartman

This study shows temozolomide causes RNA alkylation and widespread translational repression in glioblastoma cells by targeting guanine-rich transcripts.

The paper investigates factors influencing yeast quiescence using defined media, revealing interactions between auxotrophy, nutrient availability, and signaling pathways.

The paper uses yeast phenomics to model how Warburg metabolism affects genetic buffering of doxorubicin, identifying key biological processes and predicting causal gene expression effects on anti-cancer efficacy.

The paper uses a humanized yeast model to predict genetic buffering of nucleoside analog cytotoxicity by analyzing drug-gene interactions in cancer cell lines.