Author

Daniël de Groot

The Netherlands Cancer Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Ben MorrisiD· 2 shared Heinz JacobsiD· 2 shared Maaike KreftiD· 2 shared Aldo SpanjaardiD· 1 shared Bas PilzeckeriD· 1 shared Camiel GöbeliD· 1 shared Cor LieftinkiD· 1 shared Daan J. KloostermaniD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCancer Biology

Ben MorrisORCID

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2 papers

Recent·Most cited

Targeting DOT1L and EZH2 synergizes in breaking the germinal center identity of Diffuse Large B Cell Lymphoma

Camiel Göbel, Rachele Niccolai, Marnix H. P. de Groot, Jayashree Jayachandran, Joleen J.H. Traets, Daan J. Kloosterman, Sebastian Gregoricchio, Ben Morris, Maaike Kreft, Ji‐Ying Song, Leyla Azarang, Eirini Kasa, Nienke Oskam, Daniël de Groot, Liesbeth Hoekman, , Heinz Jacobs

This study shows that targeting DOT1L and EZH2 together disrupts the germinal center identity of GCB-DLBCL cells, leading to a cell-identity crisis and reduced tumor growth in vivo.

Blood · Jan 10, 2025Peer-reviewedCancer Biology

Molecular dependencies and genomic consequences of a global DNA damage tolerance defect

Daniël de Groot, Aldo Spanjaard, Ronak Shah, Maaike Kreft, Ben Morris, Cor Lieftink, Joyce J. I. Catsman, Shirley Ormel, Matilda Ayidah, Bas Pilzecker, Olimpia Alessandra Buoninfante, Paul C.M. van den Berk, Roderick L. Beijersbergen, Heinz Jacobs

The paper investigates the molecular and genomic effects of a global DNA damage tolerance defect, identifying type 3 deletions as a mutational signature of replication stress.

Genome biology · Dec 31, 2024Peer-reviewedMolecular Biology