Xintian Hu

This paper develops a tree shrew Parkinson's disease model that replicates key clinical and pathological features of PD, offering a cost-effective alternative to primate models.

This study identifies naturally occurring Alzheimer's disease in aged rhesus monkeys, showing cognitive impairments and AD pathological hallmarks.

This study shows that light intensity non-linearly affects ocular axial length growth in rhesus monkeys, with medium intensity light causing greater growth than low or high intensity light.

This study shows that maternal separation in young rhesus monkeys can induce three core ASD symptoms, suggesting early environmental adversity contributes to ASD pathogenesis.

This paper develops a high-throughput method for whole-brain imaging of rhesus monkeys at high resolution, enabling detailed connectome mapping of axonal fibers.

This study edits PINK1 and DJ-1 genes in adult monkey brains using AAV-delivered CRISPR/Cas9, resulting in Parkinsonian symptoms and pathology.

This study uses in vivo CRISPR/Cas9 to edit MECP2 in adolescent rhesus monkeys, resulting in autistic-like behaviors.

This study shows NeuroD1 gene therapy converts reactive astrocytes to neurons in adult NHP brains after stroke, increasing neuronal density and protecting interneurons.

This study uses CRISPR to knockout RHO in rhesus macaques, resulting in RP-like phenotypes and demonstrating the feasibility of creating NHP models for retinal disease research.