Yingzhou Hu

This paper develops a tree shrew Parkinson's disease model that replicates key clinical and pathological features of PD, offering a cost-effective alternative to primate models.

This study shows that light intensity non-linearly affects ocular axial length growth in rhesus monkeys, with medium intensity light causing greater growth than low or high intensity light.

This study edits PINK1 and DJ-1 genes in adult monkey brains using AAV-delivered CRISPR/Cas9, resulting in Parkinsonian symptoms and pathology.

This study uses in vivo CRISPR/Cas9 to edit MECP2 in adolescent rhesus monkeys, resulting in autistic-like behaviors.

This study uses CRISPR to knockout RHO in rhesus macaques, resulting in RP-like phenotypes and demonstrating the feasibility of creating NHP models for retinal disease research.