Xiao Li

The paper develops a host-exclusive primer design workflow for long-read metabarcoding, enabling efficient amplification of fungal rDNA from mixed DNA samples.

This study edits PINK1 and DJ-1 genes in adult monkey brains using AAV-delivered CRISPR/Cas9, resulting in Parkinsonian symptoms and pathology.

This study uses in vivo CRISPR/Cas9 to edit MECP2 in adolescent rhesus monkeys, resulting in autistic-like behaviors.

The paper uses bulk RNA-seq data to estimate cell type abundances and identifies cell type interaction QTLs that provide finer resolution of tissue specificity than bulk cis-eQTLs.

The paper examines telomere length variation across 6,391 tissue samples from 952 individuals, showing tissue-specific differences, positive correlations between tissues, and associations with age and ancestry.

Integrating expression, allelic expression and splicing across tissues identifies rare variants with relevance to traits.

This study shows that loss of endothelial FSTL1 causes atrial and vein wall fibrosis through SMAD3 activation, leading to heart failure.