Author

Shihao Wu

Kunming Institute of ZoologyORCID 0000-0002-3360-1633Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:rat· 4 Organism:mouse· 3 Organism:non-human primate· 3 Organism:human· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

Zilong QiuiD· 5 shared Xintian HuiD· 4 shared Longbao LviD· 3 shared Dongdong QiniD· 2 shared Tian‐Lin ChengiD· 2 shared Xia Ma· 2 shared Xiao LiiD· 2 shared Xiaofeng ReniD· 2 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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5 shared papersNeuroscience

Zilong QiuORCID

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8 papers

Recent·Most cited

An ASXL3-thyroid hormone axis in parvalbumin interneurons controls autism-like behaviors

Chaodong Ding, Yiting Yuan, Yixin Hu, Yuefang Zhang, Shihao Wu, Ailian Du, Zilong Qiu

This study identifies an ASXL3-thyroid hormone axis in parvalbumin interneurons that regulates autism-like behaviors and shows that early TH supplementation can reverse these effects in mice.

Science Advances · Sep 23, 2026Peer-reviewedNeuroscience

Single-Cell eQTL Mapping Reveals Cell Type-Specific Genetic Regulation in Lung Cancer

Yating Fu, Yi Wang, Chen Jin, Chang Zhang, Jiaying Cai, Linnan Gong, Chenying Jin, Gang Chen, Yuanlin Mou, Caochen Zhang, Shihao Wu, Xinyuan Ge, Yahui Dai, Sunan Miao, Huimin Ma, , Hongxia Ma

This study maps single-cell eQTLs in lung tissue, revealing cell-type-specific genetic regulation and linking it to lung cancer susceptibility.

Cell Genomics · Dec 11, 2025Peer-reviewedGenetics

Remodeling of purinergic signaling in the paraventricular hypothalamus promotes hyperphagic obesity and insulin resistance

Yu Liu, Anastasiia Bondarenko, Haiyang Zhang, Pengwei Luan, Qian Zhang, Bo Wang, Syeda Sadia Najam, Xian Liang, Ali Alamdar Shah Syed, Dongfa Lin, Shangyuan Huang, Ruslan Konovalov, Witold Konopka, Zhi Long Zhang, Yi Zhang, , Ilya A. Vinnikov

This study shows that high-fat diet induces purinergic signaling in the hypothalamus, leading to obesity and insulin resistance, and that targeting P2Y12 can reverse these effects.

bioRxiv · Jul 2, 2024 · PreprintNeuroscience

Naturally occurring Alzheimer's disease in rhesus monkeys

Zhenhui Li, Xiaping He, Shihao Wu, Rongyao Huang, Hao Li, Zhengbo Wang, Limin Wang, Dongdong Qin, Yu Kong, Yingqi Guo, Xia Ma, Christoph W. Turck, Zhi‐Qi Xiong, Wenchao Wang, Xintian Hu

This study identifies naturally occurring Alzheimer's disease in aged rhesus monkeys, showing cognitive impairments and AD pathological hallmarks.

bioRxiv · Oct 20, 2022 · PreprintNeuroscience

Maternal separation induces autism spectrum disorder in young rhesus monkeys

Xiaofeng Ren, Shihao Wu, Hui Zhou, Longbao Lv, Zilong Qiu, Xiaoli Feng, Xintian Hu

This study shows that maternal separation in young rhesus monkeys can induce three core ASD symptoms, suggesting early environmental adversity contributes to ASD pathogenesis.

bioRxiv · Mar 17, 2022 · PreprintNeuroscience

Co-editing PINK1 and DJ-1 genes via AAV-delivered CRISPR/Cas9 system in adult monkey brains elicits classic Parkinsonian phenotypes

Hao Li, Shihao Wu, Xia Ma, Xiao Li, Tian‐Lin Cheng, Zhifang Chen, Jing Wu, Longbao Lv, Ling Li, Liqi Xu, Wenchao Wang, Yingzhou Hu, Haisong Jiang, Yong Yin, Zilong Qiu, Xintian Hu

This study edits PINK1 and DJ-1 genes in adult monkey brains using AAV-delivered CRISPR/Cas9, resulting in Parkinsonian symptoms and pathology.

Neuroscience Bulletin · Jun 24, 2021Peer-reviewedNeuroscience

The molecular taxonomy of primate amygdala via single-nucleus RNA-sequencing analysis

Lei Zhang, Yanyong Cheng, Shihao Wu, Yufeng Lu, Zhenyu Xue, Xiao Chen, Dai Chen, Bo Zhang, Zilong Qiu, Hong Jiang

This study identifies five major cell types in rhesus monkey amygdala using single-cell RNA sequencing, revealing unique molecular features compared to rodents.

中国科学通报：英文版 · Jan 19, 2021Peer-reviewedNeuroscience

Induction of core symptoms of autism spectrum disorders by in vivo CRISPR/Cas9-based gene editing in the brain of adolescent rhesus monkeys

Shihao Wu, Xiao Li, Dongdong Qin, Lin-Heng Zhang, Tian‐Lin Cheng, Zhifang Chen, Binbin Nie, Xiaofeng Ren, Jing Wu, Wenchao Wang, Yingzhou Hu, Yilin Gu, Longbao Lv, Yong Yin, Xintian Hu, Zilong Qiu

This study uses in vivo CRISPR/Cas9 to edit MECP2 in adolescent rhesus monkeys, resulting in autistic-like behaviors.

中国科学通报：英文版 · Dec 17, 2020Peer-reviewedNeuroscience