Pengyu Y. Ren

This paper uses simulations to study how protein condensates on opposite sides of a membrane interact via membrane-mediated forces, finding that curvature plays a major role in their coupling.

This paper develops a high-throughput platform to rapidly adapt DNA aptamers against evolving SARS-CoV-2 variants, identifying mutants with improved binding affinity and specificity.

The paper uses simulations to show that increased lipid interdigitation mediates transbilayer coupling of protein condensates by reducing lipid entropy and altering membrane curvature.

This paper optimizes a DNA-based fluorogenic aptamer (D-FAP) using a screening-and-simulation pipeline on a repurposed sequencing platform, achieving improved fluorescence properties.

This paper introduces a fluorescence-lifetime-based multiplexed detection strategy using fluorogenic aptamers to distinguish viral RNA targets with minimal cross-reactivity and spectral overlap.

This paper develops a machine learning-guided hydrogen-bonded organic framework for ultrasound-triggered pain therapy, showing effective long-term analgesia in a rat model.

This study shows fibrin fibers exhibit viscoelastic behavior and irreversible damage under cyclic loading, with damage sources identified through molecular analysis.

The paper uses molecular dynamics simulations to analyze water-glycan interactions in SARS-CoV-2 spike protein states, revealing structural and dynamic differences that impact immune evasion.