Author

Yi Lu

First Affiliated Hospital of Guangzhou Medical University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Cancer Biology· 1 Immunology· 1 Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:electronic health records· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Anjie ZheniD· 1 shared Ariel S. Peng· 1 shared Binbin WangiD· 1 shared Binyu ZhangiD· 1 shared Boxi Zhao· 1 shared Christopher Platt· 1 shared Chunhao Long· 1 shared Erik Gramajo· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperImmunology

Anjie ZhenORCID

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Author profile →

4 papers

Recent·Most cited

The HES1-SOD1 Antagonism Shapes Senescence Heterogeneity and Impacts Metastatic Relapse of Circulating Tumor Cells

Guanyin Huang, Xiaolong Xu, Binyu Zhang, Mao Zhao, Yixin Cheng, Boxi Zhao, Shuqian Zheng, Xuefei Liu, Songyan Yu, Liuyang Wang, Jianyang Hu, Chunhao Long, Yu Zhang, Yuling Sheng, Siyuan Xia, , Xin Hong

This study identifies two HES1-expressing senescent CTC subpopulations with distinct metabolic and clinical outcomes, showing HES1-SOD1 antagonism influences metastatic relapse.

bioRxiv · Aug 20, 2026 · PreprintCancer Biology

Midazolam suppresses glioma progression by attenuating neuronal activity and downregulating IGF1 signaling

Zhihui Qi, Zhiming Ye, Kahei Chan, Yumin Wu, Yu Yu, Yang Hu, Yi Lu, Jiaoyan Ren, Maojin Yao, Zhongxing Wang

This study shows midazolam inhibits glioma growth by reducing neuronal activity and IGF1 signaling in vitro and in vivo.

Acta Biochimica et Biophysica Sinica · Jun 8, 2026Peer-reviewedNeuroscience

A Novel Glia-immune humanized mouse model for investigation of HIV CNS infection and neuroinflammation.

Shallu Tomer, Lin Pan, Jeffrey S. Harding, Valerie K. Rezek, Mitchell C. Krawczyk, Ethan Cook, Nandita Kedia, Li Wang, Jonathan Le, Christopher Platt, Heather A. Martin, Erik Gramajo, Xiang Li, Yewen Zhang, Ariel S. Peng, , Anjie Zhen

This paper develops a humanized mouse model with human glia and immune cells to study HIV CNS infection and neuroinflammation, showing HIV replication and synapse loss in the brain.

bioRxiv · Mar 5, 2025 · PreprintImmunology

In-cell structural insight into the asymmetric assembly of central apparatus in mammalian sperm axoneme

Yun Zhu, Guoliang Yin, Linhua Tai, Binbin Wang, Yi Lu, Zhiyong Zhang, Su‐Ren Chen, Fei Sun

The paper solves the in-cell structure of mouse sperm central apparatus at sub-nanometer resolution and identifies proteins critical for its asymmetric assembly.

bioRxiv · Aug 6, 2024 · PreprintMolecular Biology