Zhenzhen Hou

This study identifies impaired maternal mRNA deadenylation as a molecular defect in in vitro matured mouse and human oocytes, leading to abnormal gene expression.

This study compares poly(A) tail dynamics during oocyte-to-embryo transition across four mammalian species, identifying conserved and divergent features of maternal mRNA regulation.

The paper quantifies poly(A) tail length dynamics during the mammalian oocyte-to-embryo transition and shows their role in maternal gene expression across species.

The paper profiles poly(A) tail dynamics in human oocytes and embryos, revealing dynamic changes in length and non-A residues, and identifies mechanisms for their regulation.

This study shows that gene conversion and NHEJ are major DNA repair mechanisms in human embryos, with gene conversion potentially useful for gene correction but also causing extensive loss of heterozygosity.