Author

Alanya J. Nardone

Florida State University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:electronic health records· 1 Approach:experimental assay· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein design· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Adriana CoricelloiD· 2 shared Wen ZhuiD· 2 shared Yuichiro TakagiiD· 2 shared Antonio LupiaiD· 1 shared Carmen GratteriiD· 1 shared Giovanni BottegoniiD· 1 shared Lucciano A. PearceiD· 1 shared Matthijn R. J. VosiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

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10 top collaborators · 35 mutual co-author links

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2 shared papersBiochemistry

Adriana CoricelloORCID

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2 papers

Recent·Most cited

Conformational Remodeling Underlies Activity Loss in Disease-Linked Asparagine Synthetase Variant

Lucciano A. Pearce, Adriana Coricello, Alanya J. Nardone, Giovanni Bottegoni, Yuichiro Takagi, Wen Zhu

This study investigates how a specific mutation in the ASNS gene impairs enzyme function by disrupting conformational dynamics, using biochemical, cryo-EM, and molecular dynamics approaches.

bioRxiv · Feb 3, 2026 · PreprintBiochemistry

3D Variable Analysis Reveal a Hidden Conformational Dynamics Controlling Ammonia Transport in Human Asparagine Synthetase

Adriana Coricello, Alanya J. Nardone, Antonio Lupia, Carmen Gratteri, Matthijn R. J. Vos, Vincent Chaptal, Stefano Alcaro, Wen Zhu, Yuichiro Takagi, Nigel G. J. Richards

The paper uses 3DVA and MD simulations to reveal that Arg-142 in ASNS acts as a gate controlling ammonia transport through an intramolecular tunnel.

Nature Communications · Dec 3, 2024Peer-reviewedMolecular Biology