Author

Adriana Coricello

University of UrbinoORCID 0000-0002-3306-9261Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:electronic health records· 1 Approach:experimental assay· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein design· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Alanya J. Nardone· 2 shared Wen ZhuiD· 2 shared Yuichiro TakagiiD· 2 shared Antonio LupiaiD· 1 shared Carmen GratteriiD· 1 shared Giovanni BottegoniiD· 1 shared Lucciano A. PearceiD· 1 shared Matthijn R. J. VosiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersBiochemistry

Alanya J. Nardone

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Conformational Remodeling Underlies Activity Loss in Disease-Linked Asparagine Synthetase Variant

Lucciano A. Pearce, Adriana Coricello, Alanya J. Nardone, Giovanni Bottegoni, Yuichiro Takagi, Wen Zhu

This study investigates how a specific mutation in the ASNS gene impairs enzyme function by disrupting conformational dynamics, using biochemical, cryo-EM, and molecular dynamics approaches.

bioRxiv · Feb 3, 2026 · PreprintBiochemistry

3D Variable Analysis Reveal a Hidden Conformational Dynamics Controlling Ammonia Transport in Human Asparagine Synthetase

Adriana Coricello, Alanya J. Nardone, Antonio Lupia, Carmen Gratteri, Matthijn R. J. Vos, Vincent Chaptal, Stefano Alcaro, Wen Zhu, Yuichiro Takagi, Nigel G. J. Richards

The paper uses 3DVA and MD simulations to reveal that Arg-142 in ASNS acts as a gate controlling ammonia transport through an intramolecular tunnel.

Nature Communications · Dec 3, 2024Peer-reviewedMolecular Biology