BiochemistryProceedings of the National Academy of SciencesPeer-reviewed
Mechanism of allosteric activation in human mitochondrial ClpP protease
Monica M. Goncalves, Adwaith B. Uday, Taylor J. B. Forrester…·Siavash Vahidi
This study reveals the activation mechanism of human mitochondrial ClpP protease through structures showing how inhibitors induce an allosteric transition to the active state, with implications for cancer therapy.
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