Author
University Health NetworkORCID 0000-0003-4023-3899Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Abdula Maher, Dhanoop Manikoth Ayyathan, Séverine Cathelin…·Steven M. Chan
This study identifies CD59 as a critical regulator of Ras-MAPK signaling in AML, showing its depletion impairs leukemic growth and identifies rILYd4 as a potential therapeutic target.
Andrew Chatr‐aryamontri, Li Zhang, Ndeye Khady Thiombane…·Thierry Bertomeu
The paper introduces a method for systematically studying genetic interactions in human cells using CRISPR/Cas9 screens and demonstrates its effectiveness through 26 gene by genome-wide knockout screens.
Monica M. Goncalves, Adwaith B. Uday, Taylor J. B. Forrester…·Siavash Vahidi
This study reveals the activation mechanism of human mitochondrial ClpP protease through structures showing how inhibitors induce an allosteric transition to the active state, with implications for cancer therapy.
James T. Hagen, McLane M. Montgomery, Raphael Taiwo Aruleba…·Kelsey H. Fisher‐Wellman
This study identifies a bioenergetic mechanism in AML cells where mitochondria consume ATP to resist chemotherapy, offering a target for improving treatment.