Algirdas Vėlyvis

This paper introduces a universal volatile buffer system using fluorinated ethylamines for native LC-MS analysis of antibody-based therapeutics, enabling broad pH range buffering and compatibility with mass spectrometry.

HDgraphiX visualizes HDX-MS data using statistical analysis and generates publication-quality plots and structural maps.

This study reveals the activation mechanism of human mitochondrial ClpP protease through structures showing how inhibitors induce an allosteric transition to the active state, with implications for cancer therapy.

The paper presents the first high-resolution structure of Mycobacterium tuberculosis 20S core particle in an inactive state, revealing the structural basis for allosteric regulation.