Christophe Heinrich

This study identifies how Oct4 differentially co-opts Bcl11a and Bcl11b to regulate reprogramming to pluripotency by revealing their opposing roles in cell fate conversion.

This study develops an in vitro model of brain injury that recapitulates key features of injury and regeneration, enabling the study of glia-to-neuron reprogramming and stem cell dynamics.

The paper uses single-cell RNA-sequencing to identify quiescent neural stem cells in the dorsal V-SVZ and shows that TGFbeta/BMP signalling drives their quiescence and blocks glutamatergic neurogenesis.

This study shows that adult mouse hippocampal progenitors can change lineage fate in response to chemoconvulsants, with KA promoting astrogliogenesis and PL favoring neurogenesis.