Cancer BiologyFree Radical Biology and MedicinePeer-reviewed
Pharmacological Ascorbate Induces Transient Hypoxia Sensitizing Pancreatic Ductal Adenocarcinoma to a Hypoxia Activated Prodrug
Shun Kishimoto, Daniel R. Crooks, Yasunori Otowa…·Jeffrey R Brender
This study shows that pharmacological ascorbate induces transient hypoxia in pancreatic ductal adenocarcinoma, enhancing the efficacy of the hypoxia-activated prodrug evofosfamide in some tumor models.
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