Author

Brenna J. Gittins

University of California, BerkeleyORCID 0000-0003-2457-9515Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Alexander MarsoniD· 1 shared Alissa BockmaniD· 1 shared Brian M. WeistiD· 1 shared Charlotte H. WangiD· 1 shared Chenyu ZhangiD· 1 shared Daniel Bryan GoodmaniD· 1 shared Daniel CarriD· 1 shared David N. NguyeniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperGenetic & Genomic Medicine

Alexander MarsonORCID

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2 papers

Recent·Most cited

Genetic & Genomic MedicinemedRxivPreprintApr 29, 2026

CRISPR-mediated functional mapping of IL2RG variants in primary human T cells predicts X-linked severe combined immunodeficiency

Yvonne Rong, Mikhail Vysotskiy, Peixin Amy Chen…·David N. Nguyen

The paper uses CRISPR to assess the functional impact of IL2RG variants in human T cells, confirming known annotations and identifying novel loss-of-function mutations.

DOI 10.64898/2026.04.27.26351884

humanCRISPR screen

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Cancer BiologybioRxivPreprintJun 26, 2025

Intratumoral Treg ablation is sufficient to mediate tumor control systemically without autoimmunity

Alissa Bockman, Brenna J. Gittins, Chenyu Zhang…·Michel J.P. DuPage

The paper shows that ablating tumor-infiltrating Tregs systemically controls tumors without autoimmunity, primarily through CD4+ T cells and cDC2s.

3 citations

mouseexperimental assay

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