Joseph M. Santin

This paper shows frogs can sustain neural activity without glucose metabolism by using brain-derived ketone bodies during hibernation, challenging the idea that glucose is essential for brain function.

The paper shows that cold temperature, not inactivity, reduces GABAergic signaling in bullfrog respiratory networks during overwintering.

This study shows that homeostatic synaptic plasticity increases AMPA receptor levels in motoneurons during hibernation, enhancing synaptic transmission at cool temperatures and enabling motor behavior restart after inactivity.

This study shows that hibernating frogs reduce oxygen consumption for neural activity while maintaining normal function, revealing metabolic plasticity in vertebrate brain circuits.

The paper shows that hibernation enhances neural function during hypoxia across multiple CNS regions in American bullfrogs, not just brainstem areas involved in breathing.

The paper shows that a motor circuit in amphibians uses temperature sensing, not activity sensing, to restore function after cooling-induced inactivity through noradrenergic system activation.

This study shows that hibernation modifies NMDA receptor properties to enhance neural stability during hypoxia without affecting normal function.

The paper examines the synaptic contributions of pacemaker neurons in the Jonah crab's pyloric network, finding that the glutamatergic AB neuron contributes more than the cholinergic PD neuron.

The paper evaluates how accurately transcriptional profiling can classify neuronal cell types using small crustacean ganglia, finding that expression profiles alone are insufficient without additional modalities.