Transforming neural activity to operate without glucose metabolism using brain-derived ketone bodies
Hafsa Yaseen, Karissa Cisneros, Rebecca Wright, Nikolaus Bueschke, Joseph M. Santin
This paper shows frogs can sustain neural activity without glucose metabolism by using brain-derived ketone bodies during hibernation, challenging the idea that glucose is essential for brain function.
Proceedings of the National Academy of Sciences · Sep 2, 2026Peer-reviewedPhysiology