Author

Yoshiaki Kobayashi

Kyushu UniversityORCID 0000-0002-9585-7255Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:imaging· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:fluorescence / live-cell microscopy· 1

Frequent Co-Authors

Hiroshi OchiaiiD· 3 shared Hiroaki OhishiiD· 2 shared Satoshi UchinoiD· 2 shared Xiaohui Gao· 2 shared Yasuyuki OhkawaiD· 2 shared Akane KawaguchiiD· 1 shared Akihito HaradaiD· 1 shared Angelika FeldmanniD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersMolecular Biology

Hiroshi OchiaiORCID

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Author profile →

4 papers

Recent·Most cited

Cohesin prevents local mixing of condensed euchromatic domains in living human cells

Masa A. Shimazoe, Shiori Iida, Katsuhiko Minami, Koichi Higashi, Sachiko Tamura, Yoshiaki Kobayashi, Shin Fujishiro, Le Xiong, Kako Nakazato, S. S. Ashwin, Tomoko Nishiyama, Yu Nagata, Masato T. Kanemaki, Akane Kawaguchi, Yasuyuki Ohkawa, , Kazuhiro Maeshima

This study shows cohesin maintains condensed euchromatic domains in human cells by preventing local mixing, which is crucial for transcriptional insulation.

Nature Genetics · Sep 1, 2026Peer-reviewedCell Biology

Minute-scale coupling of chromatin marks and transcriptional bursts

Xiaohui Gao, Chaebeen Ko, Yuanchao Dong, Takeru Fujii, Satoshi Uchino, Yoshiaki Kobayashi, Akihito Harada, Hiroaki Ohishi, Yasuyuki Ohkawa, Hiroshi Kimurâ, Hiroshi Ochiai

The paper shows that chromatin modifications around genes fluctuate with transcriptional activity in mouse embryonic stem cells, revealing minute-scale coupling between histone marks and transcriptional bursts.

bioRxiv · Feb 10, 2026 · PreprintMolecular Biology

SNPD-siKRAS: siRNA specifically inhibits KRAS with a single-nucleotide mutation

Yoshiaki Kobayashi, Yoshimasa Asano, Atsushi Sato, Hiroaki Taniguchi, Kumiko Ui-Tei

This paper develops SNPD-siKRAS, a siRNA that specifically targets mutated KRAS without affecting wild-type KRAS, showing efficacy in cell cultures and xenograft models.

bioRxiv · Sep 18, 2025 · PreprintMolecular Biology

RNA-mediated SOX2 temporal dynamics govern dual chromatin engagement modes at Nanog

Bitong Li, Yew Yan Wong, Yoshiaki Kobayashi, Neftali Flores Rodriguez, Tara‐Lynne Davidson, Matthew S. Graus, Valeriia Smialkovska, Shikha Pachauri, Susav Pradhan, Xiaohui Gao, Satoshi Uchino, Hiroaki Ohishi, Angelika Feldmann, Hiroshi Ochiai, Mathias François

The paper uses single-molecule imaging to show RNA fluctuations modulate SOX2 dynamics at the Nanog locus, revealing RNA-dependent feedback in transcriptional regulation.

bioRxiv · Sep 10, 2024 · PreprintMolecular Biology