BiochemistryArchives of Biochemistry and BiophysicsPeer-reviewed
Specificity profiling of SARS-CoV-2 PLpro using proteome-derived libraries of linear peptides suggests secondary preference for basic motifs
Daniel Vogele, Klemens Fröhlich, Oguz Bolgi…·Oliver Schilling
This study identifies SARS-CoV-2 PLpro's preference for basic amino acids at P1 and secondary motifs involving two basic residues, revealing structural constraints and implications for inhibitor design.
DOI 10.1016/j.abb.2026.110840