Nian Wang

This study shows that WAY-100635, a 5-HT1A antagonist, reduces chronic neurodegeneration and immune activation after TBI by preserving neurons, synapses, and visual function.

This paper develops a human myelin microphysiological system to test treatment responses in multiple sclerosis patients, showing differential demyelination and immune responses between patient groups.

This study identifies WAY-100635 as a neuroprotectant that reprograms metabolism to promote RGC differentiation and regeneration in glaucoma models.

This paper develops a deep learning framework combining high-resolution MRI and spatial transcriptomics to create a whole-brain mouse cell type atlas at 10 micrometer resolution.

This paper presents an OECT-based sensor for rapid, sensitive detection of extracellular vesicles in Alzheimer's disease, showing improved sensitivity and reduced detection time.

This study characterizes molecular and synaptic changes in a mouse model of late-onset Alzheimer's disease under different dietary conditions, showing age-related brain volume loss and cognitive deficits.

The paper identifies a PLCG2 variant, PLCG2M28L, associated with increased Alzheimer's disease risk and altered microglial phenotypes, while another variant, PLCG2P522R, reduces disease risk in a mouse model.

This study identifies KMT2D-NOTCH signaling defects in HLHS coronary artery endothelial cells, showing impaired differentiation and proliferation due to suppressed NOTCH target genes.

This study investigates how resolution and b value affect structural connectome in ex vivo mouse brains, finding that higher angular resolution and b value improve tractography and connectome stability.

HiDiver integrates multimodal brain imaging data to enable 3D quantitative analysis of brain structure and function in mice.

The paper develops a combined MRI and light sheet imaging approach to generate high-resolution brain phenotypes for neurogenetic studies in mice.

This study examines the heritability of mouse brain connectomes using high-resolution MRI and finds high heritability in brain volumes and diffusion metrics.