Author

Michelle L. Surma

Indiana University School of MedicineORCID 0000-0002-5979-1682Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Research Focus:cell-cell communication· 1 Assay:proteomics· 1

Frequent Co-Authors

Arupratan DasiD· 2 shared Kavitha AnbarasuiD· 2 shared Sayanta Dutta· 2 shared Avinash SoundararajaniD· 1 shared Emma H. DoudiD· 1 shared Jason S. MeyeriD· 1 shared Jie Chen· 1 shared Jingwei MengiD· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersNeuroscience

Arupratan DasORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

The 5-HT1A receptor antagonist WAY-100635 maleate reprograms metabolism to promote RGC differentiation and regeneration in retino-visual centers

Sayanta Dutta, Michelle L. Surma, Jie Chen, Kavitha Anbarasu, Jingwei Meng, Nian Wang, Arupratan Das

This study identifies WAY-100635 as a neuroprotectant that reprograms metabolism to promote RGC differentiation and regeneration in glaucoma models.

Communications Medicine · Apr 2, 2026Peer-reviewedNeuroscience

Loss of Cathepsin K impairs collagen biogenesis and enhances actin polymerization in trabecular meshwork

Avinash Soundararajan, Krishna Jayasankar, Emma H. Doud, Rodahina Philihina Pasteurin, Michelle L. Surma, Padmanabhan Paranji Pattabiraman

This study shows that loss of Cathepsin K disrupts collagen biogenesis, ECM homeostasis, and actin polymerization in trabecular meshwork cells, potentially affecting aqueous humor outflow and IOP regulation.

Investigative Ophthalmology & Visual Science · Jan 30, 2026Peer-reviewedCell Biology

Enhanced mitochondrial biogenesis promotes neuroprotection in human stem cell derived retinal ganglion cells of the central nervous system

Michelle L. Surma, Kavitha Anbarasu, Sayanta Dutta, Leonardo J. Olivera Perez, Kang-Chieh Huang, Jason S. Meyer, Arupratan Das

The paper identifies that enhancing mitochondrial biogenesis through TBK1 inhibition protects glaucomatous retinal ganglion cells from mitochondrial damage.

bioRxiv · Jun 27, 2022 · PreprintNeuroscience