Marcos Simões-Costa

This study shows lactate epigenetically regulates cell states in H3K27M diffuse midline gliomas by modifying histones, and targeting CBP/p300 reduces tumor heterogeneity and improves preclinical outcomes.

The paper shows that the epigenome is spatially patterned during vertebrate gastrulation, using chromatin gradients to infer cell positions in avian embryos.

This study shows that active endogenous retroviruses in zebrafish encode Gag proteins essential for embryonic development, with specific roles in mesoderm and neural crest formation.

The paper shows that AP-2ε reprograms vomeronasal sensory neurons and their behaviors by controlling gene expression, bypassing cellular plasticity restrictions.