Matthew B. Avison

The paper analyzes antibiotic-resistant E. coli from cattle and sheep farms to identify clonal dissemination pathways and assess the impact of antibiotic withdrawal on resistance patterns.

This study compares antibiotic-resistant E. coli from raw meat, commercial raw dog food, and human infections, finding close genetic links between them.

This study finds that higher local temperatures and humidity are linked to increased antimicrobial resistance in E. coli from dairy farms, highlighting the need to account for environmental factors in AMR surveillance.

The paper identifies nitrofurantoin-resistant and pre-resistant E. coli clones in poultry and humans across multiple countries, linking them to historical antibiotic use in poultry farming.

The paper shows that E. coli phylogeny influences blaTEM-1 expression and co-amoxiclav resistance through lineage-specific regulatory differences.

The paper shows that gene cassettes in an integron, amplified by IS26, confer resistance to amikacin and piperacillin/tazobactam, often leaving meropenem as the last-resort antibiotic.

The paper identifies specific amino acid substitutions in NfsA and NfsB that reduce enzyme activity and cause nitrofurantoin resistance in E. coli, but finds that WGS alone cannot reliably predict resistance due to functional silent mutations and downregulated gene expression.

Hound maps genotype to phenotype in bacterial genomes by de novo assembly, gene detection, and mutation reporting, demonstrating its utility in predicting antibiotic resistance.

The paper characterizes iuc3-carrying plasmids in Klebsiella pneumoniae isolates, identifying convergent plasmids with resistance and virulence genes and highlighting their global epidemiology.