Author

Michael R. Ardern‐Jones

University Hospital Southampton NHS Foundation TrustORCID 0000-0003-1466-2016Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Systems Biology· 2

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Andrés F. VallejoiD· 2 shared James DaviesiD· 2 shared Kalum ClaytoniD· 2 shared Marta Ewa PolakiD· 2 shared Sofía SirventiD· 2 shared Ben D. MacArthuriD· 1 shared Gemma DouilhetiD· 1 shared Gemma Porter· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersSystems Biology

Andrés F. VallejoORCID

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2 papers

Recent·Most cited

Rank Selection Genetic Algorithm optimises robust parameter estimation for systems biology models

Gemma Douilhet, Mahesan Niranjan, Andrés F. Vallejo, Kalum Clayton, James Davies, Sofía Sirvent, Jenny Pople, Michael R. Ardern‐Jones, Marta Ewa Polak

This paper introduces GARS, a genetic algorithm with rank selection, for parameter estimation in biological models, showing strong accuracy and superiority over existing methods.

bioRxiv · Feb 22, 2022 · PreprintSystems Biology

Single cell transcriptomic analysis identifies Langerhans cells immunocompetency is critical for ability to induce tolerogenic T cells.

James Davies, Sofía Sirvent, Andrés F. Vallejo, Kalum Clayton, Gemma Porter, Patrick S. Stumpf, Jonathan J. West, Michael R. Ardern‐Jones, Harinder Singh, Ben D. MacArthur, Marta Ewa Polak

The paper identifies that Langerhans cells (LCs) upregulate a tolerogenic gene module during migration, which is critical for inducing regulatory T cells.

bioRxiv · Dec 20, 2019 · PreprintSystems Biology