Anthony D. Umpierre

The paper identifies astrocyte-to-microglia purinergic signaling as a mechanism converting neuronal hypoactivity into synapse-selective microglial regulation of circuit activity.

This study shows that microglial SWELL1 deficiency increases male-specific seizure severity but protects neurons through impaired phagocytosis and reduced neuroactive metabolite release.

This study shows that activating microglial Gi signaling reduces microglial activity and disrupts neuronal synchronization.

The paper identifies rod-shaped microglia in a TDP-43 mouse model that interact with neuronal dendrites to reduce cortical hyperexcitability and protect against neurodegeneration.

The paper identifies UDP-P2Y6 signaling as a key driver of microglial calcium activity, phagocytosis, and neuroinflammation during epileptogenesis.

The paper shows that microglial process dynamics shield GABAergic inputs to enhance neuronal activity after anesthesia in mice.

This study shows that optogenetic activation of spinal microglia in mice induces chronic pain through IL-1 signaling and increased neuronal activity.

This study investigates microglial calcium signaling in vivo, finding that microglial processes respond to changes in neuronal activity through calcium transients, while somatic calcium changes occur only after seizures.

This study shows that neuronal activity in awake mice influences microglial process surveillance via norepinephrine signaling, highlighting the need for awake imaging in studying microglia-neuron interactions.