Dimitrios Kleidonas

Genetic drivers shape TREM2-dependent myeloid responses and glioblastoma progression

This study shows TREM2's role in glioblastoma depends on genetic context and timing, with different effects in Nf1-silenced/Ras-driven and PDGFB-driven models.

Astrocyte-to-microglia purinergic signaling mediates synaptic shielding and promotes neuronal activity

The paper identifies astrocyte-to-microglia purinergic signaling as a mechanism converting neuronal hypoactivity into synapse-selective microglial regulation of circuit activity.

Microglial SWELL1 Deficiency Drives Male-Specific Seizure Vulnerability but Paradoxical Neuroprotection through Impaired Phagocytosis

This study shows that microglial SWELL1 deficiency increases male-specific seizure severity but protects neurons through impaired phagocytosis and reduced neuroactive metabolite release.

Daily repetitive magnetic stimulation induces microglia-dependent homeostatic synaptic remodeling

This study shows that repeated rTMS induces microglia-dependent synaptic remodeling in pyramidal neurons, reducing synaptic strength and spine density.

Satellite microglia gate neuronal excitability by shielding inhibitory synapses in adult brain

This study identifies satellite microglia in adult mice that modulate inhibitory synapses and neuronal activity by physically shielding inhibitory connections.

Chemogenetic activation of microglial Gi signaling decreases microglial surveillance and impairs neuronal synchronization

This study shows that activating microglial Gi signaling reduces microglial activity and disrupts neuronal synchronization.

The lincRNA Pantr1 is a FOXG1 target gene conferring site-specific chromatin binding of FOXG1

The paper identifies Pantr1 as a lncRNA regulated by FOXG1 that facilitates FOXG1's site-specific chromatin binding and impacts neuronal development.

The amyloid precursor protein regulates synaptic transmission at medial perforant path synapses

This study investigates the role of amyloid precursor protein (APP) in synaptic transmission at medial perforant path synapses using organotypic cultures and finds that presynaptic APP affects neurotransmission efficacy.

Tumor necrosis factor α modulates excitatory and inhibitory neurotransmission in a concentration-dependent manner

This study shows that TNF affects excitatory and inhibitory neurotransmission differently at low and high concentrations, with high concentrations activating microglia and inducing homeostatic effects.

Microglia mediate synaptic plasticity induced by 10 Hz repetitive transcranial magnetic stimulation

This study shows that 10 Hz rTMS induces synaptic plasticity via microglia-released cytokines, with TNF and IL6 playing a key role.