Author

Abhijeet S. Barath

Mayo ClinicORCID 0000-0002-7019-5670Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Assay:electronic health records· 1 Research Focus:fine-mapping· 1 Organism:human· 1

Frequent Co-Authors

Aastha DheeriD· 3 shared Dale B. BoscoiD· 3 shared Koichiro HaruwakaiD· 3 shared Long‐Jun WuiD· 3 shared Jiaying ZhengiD· 2 shared Lingxiao WangiD· 2 shared Shunyi ZhaoiD· 2 shared Thanh Thanh L. NguyeniD· 2 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersNeuroscience

Aastha DheerORCID

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Author profile →

4 papers

Recent·Most cited

Microglial SWELL1 Deficiency Drives Male-Specific Seizure Vulnerability but Paradoxical Neuroprotection through Impaired Phagocytosis

Abhijeet S. Barath, Aastha Dheer, Laura Montier, Mekenzie M Peshoff, Emily C. Dale, Flavia Goche, Thanh Thanh L. Nguyen, Mastura Akter, Fangfang Qi, Dimitrios Kleidonas, Lauren Harris, Sarah A. Jewanee, Anthony D. Umpierre, Dale B. Bosco, Koichiro Haruwaka, , Long‐Jun Wu

This study shows that microglial SWELL1 deficiency increases male-specific seizure severity but protects neurons through impaired phagocytosis and reduced neuroactive metabolite release.

JCI Insight · Jun 21, 2026Peer-reviewedNeuroscience

Impaired microglial phagocytosis promotes seizure development

Dale B. Bosco, Václav Křemen, Koichiro Haruwaka, Shunyi Zhao, Lingxiao Wang, Blake A. Ebner, Jiaying Zheng, Manling Xie, Aastha Dheer, Jadyn F. Perry, Abhijeet S. Barath, Aivi T. Nguyen, Gregory A. Worrell, Long‐Jun Wu

The paper shows that impaired microglial phagocytosis due to TREM2 deficiency promotes seizure development in mice and correlates with seizure history in human patients.

Brain, Behavior, and Immunity · Jan 1, 2025Peer-reviewedNeuroscience

Chemogenetic approaches reveal dual functions of microglia in epilepsy

Aastha Dheer, Dale B. Bosco, Jiaying Zheng, Lingxiao Wang, Shunyi Zhao, Koichiro Haruwaka, Min‐Hee Yi, Abhijeet S. Barath, Dai‐Shi Tian, Long‐Jun Wu

This study uses chemogenetic manipulation to show that microglia have both seizure-reducing and seizure-promoting effects in a mouse epilepsy model.

bioRxiv · May 28, 2023 · PreprintNeuroscience

Glucocorticoids Unmask Silent Non-Coding Genetic Risk Variants for Common Diseases

Thanh Thanh L. Nguyen, Huanyao Gao, Duan Liu, Trudy Janice Philips, Zhenqing Ye, Jeong‐Heon Lee, Geng‐Xian Shi, Kaleigh M. Copenhaver, Lingxin Zhang, Lixuan Wei, Jia Yu, Huan Zhang, Abhijeet S. Barath, Maggie Luong, Cheng Zhang, , Richard M. Weinshilboum

The paper shows glucocorticoid exposure reveals the function of non-coding genetic variants linked to disease risk by influencing gene expression in relevant biological processes.

Nucleic Acids Research · Nov 11, 2022Peer-reviewedGenomics