Yu Zhu

This paper develops a unified ensemble-allosteric framework to explain how gain- and loss-of-function mutations in IP3R1 cause disease by altering conformational dynamics and allosteric communication.

This study identifies key molecular determinants of ligand selectivity and sensitivity in a dopamine-gated ion channel from Daphnia, revealing how structural changes affect pharmacology.

This paper uses deep learning to analyze the co-evolutionary dynamics of L2 β-lactamases and their functional mechanisms.