Taufiq Rahman

The paper identifies three GCN2 activators, one of which works independently of GCN1, and describes its unique binding mechanism.

This paper develops a unified ensemble-allosteric framework to explain how gain- and loss-of-function mutations in IP3R1 cause disease by altering conformational dynamics and allosteric communication.

The paper identifies a unique bi-functional monooxygenase in Toxoplasma gondii essential for ubiquinone biosynthesis and presents inhibitors targeting this enzyme.

This study identifies key molecular determinants of ligand selectivity and sensitivity in a dopamine-gated ion channel from Daphnia, revealing how structural changes affect pharmacology.

This study functionally and pharmacologically characterizes the store-operated calcium entry pathway in naked mole-rat cells using both excitable and non-excitable cells.

This study models the full-length Epstein-Barr virus LMP1 protein and identifies potential drug targets in its C-terminus domain.

This study uses electrophysiology and in silico modeling to propose binding sites and modes of action for four CRAC channel inhibitors.

The paper develops and evaluates machine learning scoring functions for identifying PARP1 inhibitors, finding a support vector machine-based model with PLEC fingerprints outperforms others in virtual screening.

This study uses molecular dynamics simulations to uncover the dynamic interactions and conformational changes in the N-terminal domain of IP3 receptor during IP3 binding, revealing key molecular events in receptor activation.