Jens H. Gundlach

Single-molecule nanopore-tweezers analysis of transcription elongation by intact and "stalk-less" yeast RNA polymerase II

Nanopore tweezers enable monitoring of RNA polymerase II translocation relative to DNA during transcription elongation with single-nucleotide spatial resolution and millisecond-scale temporal resolution at biologically relevant, saturating substrate concentrations.

Lumen charge governs gated ion transport in β-barrel nanopores

This study identifies and characterizes nonlinear ion transport phenomena in β-barrel nanopores, linking lumen charge distribution to open-pore rectification and gating.

Mechanism of an animal toxin-antidote system

This study identifies PMPL-1 as a cofactor required for PEEL-1 toxin-induced cell death in C. elegans and shows that the toxin-antidote system creates a cation channel.

UPF1 mutants with intact ATPase but deficient helicase activities promote efficient nonsense-mediated mRNA decay

The paper identifies UPF1 mutants with impaired helicase activity but intact ATPase activity that still support efficient nonsense-mediated mRNA decay in human cells.