Karin Schann

This study establishes the formyl phosphate route for formate assimilation in E. coli through adaptive evolution and rational engineering, enabling formate-dependent growth.

The paper introduces the Serine Shunt as a novel formate reduction pathway in E. coli, demonstrating its in vivo activity and efficiency for converting formate to formaldehyde.

This paper engineers the bacterium C. necator to convert formate into crotonate, achieving higher titer, productivity, and yield through metabolic pathway optimization.

The paper engineers a synthetic C1-assimilation cycle in E. coli to enable growth on formate, demonstrating the feasibility of synthetic carbon fixation from CO2.