CNS Neuroscience & TherapeuticsNeurosciencePeer-reviewed journal article
A marked enhancement of a BLOC-1 gene, pallidin, associated with somnolent mouse models deficient in histamine transmission
Laurent SeugnetiD, Christelle AnacletiD, Magali PerieriD, Jean‐François Ghersi‐EgeaiD, Jian‐Sheng LiniD
Abstract
Histamine (HA) and orexin (Ox, or hypocretin) neurons act distinctly and synergistically in wake control. A double knock out mouse genotype lacking both HA and Ox shows all sleep disorders of human narcolepsy. We identified in this mouse brain a sharp upregulation of a BLOC-1 gene, pallidin that is associated with dramatic changes in the balance of cholinergic and aminergic systems in mice and an enhanced sleep in drosophila. This study demonstrates potential sleep disorders-associated compensatory mechanisms with pallid as a novel biomarker.
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