Xiaolong Wang

TRU-PE improves prime editing efficiency and scalability for genome engineering in human cells, enabling multi-locus edits and a platform for studying genetic disorders.

The paper quantifies evolutionary constraint on the branch point sequence in 30 species using public variant databases, finding biased variants in 16 species and identifying constrained positions in 14.

This study identifies introgression and selection events in goat domestication, linking them to immune and behavioral genes.

This study uses base editing in goat embryos to introduce nonsense mutations in FGF5, improving cashmere yield with minimal off-target effects.