Chao Li

Seipin and perilipin 3 promote distinct early steps of nascent lipid droplet biogenesis

This study identifies seipin and perilipin 3 as distinct regulators of early lipid droplet biogenesis by promoting nucleation and stabilizing nascent droplets, respectively.

Unrestrained fatty acid oxidation triggers heart failure in mice via cardiolipin loss and mitochondrial dysfunction

This study shows that excessive fatty acid oxidation in mice leads to heart failure through cardiolipin loss and mitochondrial dysfunction, suggesting that increasing FAO may be harmful in heart failure.

A comparison of adiponectin-deficient mice reveals the fundamental role of intracellular adiponectin

This study compares adiponectin-deficient mice to show that intracellular globular adiponectin regulates adipose tissue metabolism by modulating PPARγ activity.

Exploiting public databases of genomic variation to quantify evolutionary constraint on the branch point sequence in 30 plant and animal species

The paper quantifies evolutionary constraint on the branch point sequence in 30 species using public variant databases, finding biased variants in 16 species and identifying constrained positions in 14.

Base pair editing of goat embryos: nonsense codon introgression into FGF5 to improve cashmere yield

This study uses base editing in goat embryos to introduce nonsense mutations in FGF5, improving cashmere yield with minimal off-target effects.