Yan Zhuge

The paper describes the generation of an iPSC line from a patient with immune checkpoint inhibitor-induced myocarditis and type I diabetes, highlighting its pluripotency and potential for studying disease mechanisms.

The paper generates three iPSC lines from an ICIM patient and controls to study disease mechanisms and develop therapies.

The paper demonstrates that micropatterned human pluripotent stem cells can model early human cardiac vascularization in vitro, resembling a 6.5 post-conception week heart and revealing conserved vascular development programs.

The paper establishes a cardiomyopathy stem cell biobank and identifies transcriptomic subtypes and drug response in iPSC-derived cardiomyocytes.