Ioannis Karakikes

Shared and Divergent Features of Cardiac Transcriptome and Glucose Metabolism Markers in Human and Mouse HFpEF

This study compares cardiac transcriptome and glucose metabolism markers in human and mouse HFpEF, finding greater conservation in right ventricles and sex-specific differences in left ventricles.

The MIRO1-BAX Complex Dictates Life and Death at the Mitochondrial Gate

This study identifies MIRO1 as a context-specific modulator of BAX activity, showing it drives distinct cell death pathways in glioma cells and Parkinsonian neurons through different mechanisms.

Micropatterned Organoids Enable Modeling of the Earliest Stages of Human Cardiac Vascularization

The paper demonstrates that micropatterned human pluripotent stem cells can model early human cardiac vascularization in vitro, resembling a 6.5 post-conception week heart and revealing conserved vascular development programs.

Artery-on-chip demonstrates smooth muscle function comparable to both healthy and diseased living tissues

The paper develops an artery-on-chip model using human iPSC-derived cells to replicate arterial function and disease states, showing comparable tissue mechanics and disease phenotypes.

Personalized transcriptome signatures in a cardiomyopathy stem cell biobank

The paper establishes a cardiomyopathy stem cell biobank and identifies transcriptomic subtypes and drug response in iPSC-derived cardiomyocytes.

Genetic analysis and multimodal imaging identify novel mtDNA 12148T>C leading to multisystem dysfunction with tissue-specific heteroplasmy

The paper identifies a novel mtDNA variant m.12148T>C associated with multisystem dysfunction and highlights the importance of tissue-specific heteroplasmy analysis.

Deep learning the cis-regulatory code of chromatin dynamics during cellular reprogramming

The paper uses deep learning to analyze chromatin accessibility and gene expression during reprogramming, revealing how TF concentrations and motif syntax influence cis-regulatory networks.

Integrative single-cell analysis of cardiogenesis identifies developmental trajectories and non-coding mutations in congenital heart disease

This study uses single-cell chromatin accessibility analysis to identify developmental trajectories and non-coding mutations associated with congenital heart disease.

SARS-CoV-2 susceptibility and ACE2 gene variations within diverse ethnic backgrounds

The paper analyzes ACE2 gene variants in a diverse UK cohort to assess their association with SARS-CoV-2 infection risk and severity, identifying variants that affect ACE2 expression and viral receptor affinity.