Peiru Chen

The paper repurposes marine bacteria to convert lignin-derived carbon into valuable chemicals using seawater, achieving carbon and water conservation.

This paper develops sequence-defined digital bottlebrush polymers for targeted oligonucleotide delivery, achieving organ-specific therapeutic effects in a mouse model.

This paper develops a bottlebrush polymer-conjugated aptamer (pacDNA) to improve aptamer stability and efficacy in targeting AXL, showing reduced cancer cell migration and tumor growth in a xenograft model.

This paper expands prime editing capabilities by utilizing non-canonical cleavage to enable editing in the 5' direction of a classic nick site.

This paper develops a streamlined prime editing system for Escherichia coli Nissle 1917, achieving high editing efficiencies and reduced off-target effects for DNA deletion, insertion, and substitution.

This paper engineers Bacillus subtilis spores to deliver lactate oxidase to the gut, reducing blood lactate in mice without disrupting microbiota or organ function.

This paper develops sequence-controlled PEG bottlebrush polymers for enhanced oligonucleotide delivery, showing improved cellular uptake and in vivo antisense activity through optimized chemical modifications.