This paper develops sequence-defined digital bottlebrush polymers for targeted oligonucleotide delivery, achieving organ-specific therapeutic effects in a mouse model.

Journal of the American Chemical Society · Sep 2, 2026Peer-reviewedBioengineering

Making Aptamers More Antibody-like: Targeting AXL in Vivo Using a Bottlebrush Polymer-Conjugated Aptamer

Tingyu Sun, Jiachen Lin, Chenyang Xue, Yuyan Wang, Peiru Chen, Yun Wei, Guobin Xu, Anais Sidonia, Chris Nenopoulos, Hossam Tashkandi, Caroline Shen, Allison Wang, Alex Wang, Ke Zhang

This paper develops a bottlebrush polymer-conjugated aptamer (pacDNA) to improve aptamer stability and efficacy in targeting AXL, showing reduced cancer cell migration and tumor growth in a xenograft model.

Advanced Healthcare Materials · Jun 26, 2025Peer-reviewedCancer Biology

Bottlebrush polymers with sequence-controlled backbones for enhanced oligonucleotide delivery

Yun Wei, Peiru Chen, Mengqi Ren, Deng Li, Jiachen Lin, Tingyu Sun, Yuyan Wang, Shaobo Yang, Christopher Nenopoulos, Christopher Oetheimer, Yao Li, Chenyang Xue, Mona S. Minkara, Ke Zhang

This paper develops sequence-controlled PEG bottlebrush polymers for enhanced oligonucleotide delivery, showing improved cellular uptake and in vivo antisense activity through optimized chemical modifications.

Journal of the American Chemical Society · Nov 27, 2024Peer-reviewedBioengineering