Author

Caroline Shen

Northeastern University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Bioengineering· 1 Cancer Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Organism:mouse· 2 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Alex WangiD· 2 shared Chenyang XueiD· 2 shared Jiachen Lin· 2 shared Ke ZhangiD· 2 shared Peiru CheniD· 2 shared Tingyu Sun· 2 shared Yun WeiiD· 2 shared Yuyan WangiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBioengineering

Alex WangORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Sequence-Defined Digital Bottlebrush Polymers for Programmable Oligonucleotide Delivery

Jiachen Lin, Tingyu Sun, Yun Wei, Chenyang Xue, Guobin Xu, Peiru Chen, Yuyan Wang, Shaobo Yang, Chloe Cavazos, Caroline Shen, Alex Wang, Ke Zhang

This paper develops sequence-defined digital bottlebrush polymers for targeted oligonucleotide delivery, achieving organ-specific therapeutic effects in a mouse model.

Journal of the American Chemical Society · Sep 2, 2026Peer-reviewedBioengineering

Targeted Photodegradation of Misfolded Proteins via Self-photosensitizing with Molecularly Produced Light

H Wang, Shiju Gu, Yu Jiang, Jinwu Yan, Jing Zhang, Zhiyong Jiang, Caroline Shen, Jun Yang, Chongzhao Ran

This study demonstrates that molecularly produced light from ADLumin-5 can degrade misfolded proteins like beta-amyloid and reduce their toxicity in vitro and in vivo.

bioRxiv · Jun 22, 2026 · PreprintNeuroscience

Making Aptamers More Antibody-like: Targeting AXL in Vivo Using a Bottlebrush Polymer-Conjugated Aptamer

Tingyu Sun, Jiachen Lin, Chenyang Xue, Yuyan Wang, Peiru Chen, Yun Wei, Guobin Xu, Anais Sidonia, Chris Nenopoulos, Hossam Tashkandi, Caroline Shen, Allison Wang, Alex Wang, Ke Zhang

This paper develops a bottlebrush polymer-conjugated aptamer (pacDNA) to improve aptamer stability and efficacy in targeting AXL, showing reduced cancer cell migration and tumor growth in a xenograft model.

Advanced Healthcare Materials · Jun 26, 2025Peer-reviewedCancer Biology