Alessandra Sacco

This study identifies SAA1-TLR4 signaling as a tumor-derived pathway driving muscle wasting in pancreatic cancer, showing that targeting this pathway can preserve muscle mass and improve survival without affecting tumor growth.

This study shows that targeting CCND1-CDK6 reduces DNA damage, inflammation, and age-related decline in mice by suppressing SASP and ISG expression.

This study shows that aging-induced CD44 in hepatocytes activates the IL6/JAK/STAT3 pathway, leading to impaired T cell function in the liver.

This study identifies Tenascin-C as a key factor promoting muscle stem cell self-renewal through Annexin A2 signaling, showing its role in muscle repair and aging.

The paper shows that modulating the JAK2-STAT3 pathway enhances the yield and maturation of human iPSC-derived myogenic progenitor cells for potential cell therapy.

This study shows that aged livers have heightened interferon signaling that suppresses cancer but also has harmful effects, leading to a 'precarious balance' in tumor development.