Author

Mengqian Chen

University of South CarolinaORCID 0000-0003-1706-9509Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Igor B. RoninsoniD· 2 shared Alexander Albertovich ShtiliD· 1 shared Alexandra V. BruteriD· 1 shared Alexey V. FeoktistoviD· 1 shared Alissa Richmond ArmstrongiD· 1 shared Alvina I. KhamidullinaiD· 1 shared Alyona I. NikiforovaiD· 1 shared Anna V. TvorogovaiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersCancer Biology

Igor B. RoninsonORCID

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3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintJul 24, 2026

Abbapolin inhibitors of the PLK1 PBD as Prostate Cancer Therapeutics, in vivo activity and synergy with androgen therapy

George Merhej, Gurusankar Ramamoorthy, Danda P. Chapagai…·Campbell McInnes

This study develops and characterizes abbapolins, non-peptidic PLK1 PBD inhibitors, showing in vivo efficacy against prostate cancer and synergy with enzalutamide.

DOI 10.64898/2026.07.02.736204

humanproteomics

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Cancer Biologynpj Breast CancerPeer-reviewedJan 17, 2026

Host-derived Interleukin 1α induces an immunosuppressive tumor microenvironment via regulating monocyte-to-macrophage differentiation

Manikanda Raja Keerthi Raja, Gourab Gupta, Grace Atkinson…·Hexin Chen

This study shows that host-derived IL-1α promotes an immunosuppressive tumor microenvironment by regulating monocyte-to-macrophage differentiation in breast cancer.

6 citationstop 2%

mousebulk RNA-seq

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Developmental BiologyeLifePeer-reviewedApr 2, 2025

Knockout of cyclin dependent kinases 8 and 19 leads to depletion of cyclin C and suppresses spermatogenesis and male fertility in mice

Alexandra V. Bruter, Ekaterina A. Varlamova, Nina I Stavskaya…·Victor Vyacheslavovich Tatarskiy

This study shows that systemic knockout of Cdk8 and Cdk19 in mice leads to infertility due to depletion of cyclin C and impaired spermatogenesis, suggesting kinase-independent functions of CDK8/19.

8 citations

mousebulk RNA-seq

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