Author

Manikanda Raja Keerthi Raja

University of South CarolinaORCID 0009-0008-9587-8890Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Assay:metabolomics· 1 Organism:mouse· 1

Frequent Co-Authors

Daping FaniD· 2 shared Gourab Gupta· 2 shared Hexin CheniD· 2 shared Alissa Richmond ArmstrongiD· 1 shared Armando SardiiD· 1 shared Chang‐Uk Lim· 1 shared Conor PulliamiD· 1 shared Dan XueiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCancer Biology

Daping FanORCID

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2 papers

Recent·Most cited

Cancer Biologynpj Breast CancerPeer-reviewedJan 17, 2026

Host-derived Interleukin 1α induces an immunosuppressive tumor microenvironment via regulating monocyte-to-macrophage differentiation

Manikanda Raja Keerthi Raja, Gourab Gupta, Grace Atkinson…·Hexin Chen

This study shows that host-derived IL-1α promotes an immunosuppressive tumor microenvironment by regulating monocyte-to-macrophage differentiation in breast cancer.

6 citationstop 2%

mousebulk RNA-seq

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BiochemistryJournal of the American Chemical SocietyPeer-reviewedDec 28, 2024

Discovery of A Chimeric Polyketide Family as Cancer Immunogenic Chemotherapeutic Leads

Dan Xue, Mingming Xu, Michael D. Madden…·Jie Li

This paper discovers a new class of cancer immunogenic chemotherapeutic leads called aspercyclicins through a high-throughput screening platform and structural elucidation techniques.

17 citationstop 4%

metabolomicsexperimental assay

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